Membrane separation – the more effective separation of a pure enantiomer from a racemic mixture

01.01.2012 - 31.12.2015
Grant agency: 
Grant type: 
Standardní projekt
Registration number: 
Internal investigator/coinvestigator: 
Izák Pavel
Internal investigator: 
is principal investigator

Drug stereochemistry has become an issue for the pharmaceutical industry and the regulatory authorities, because each of the enantiomers frequently shows different impacts to living organisms. The goal of the proposal is to develop new membrane separation techniques for successful resolution of racemic mixtures allowing optimization of the therapeutic value of enantiomeric drugs (pharmacological and toxicological) and avoiding their adverse effects. The key objective is to separate enantiomers by a new membrane separation method, based on the proposed supported chiral room temperature ionic liquid membrane , that has never been studied yet. In comparison with classical methods employed earlier, it should show higher efficiency and cost-effectiveness in the processes of enantiomer separation. To greatly reduce the amount of experimental work, particle-based modeling will be employed. After gathering all transport characteristics, it will be possible to model the separation process and to estimate permeability and selectivity of the separation.